|
KMID : 1123920100240040592
|
|
Korean Journal of Oriental Physiology and Pathology
2010 Volume.24 No. 4 p.592 ~ p.597
|
|
|
Vasodilation of Ethanol Extract of Cinnamomi Ramulus via Voltage Dependent Ca2+ Channel Blockage
|
|
Kim Jong-Bong
Shin Heung-Mook
|
|
|
Abstract
|
|
|
|
Cinnamomi Ramulus is one of the medicinal plants that have been used to improve various diseases caused by insufficient blood circulation. This study was performed for the investigation of vasodilation efficacy ethanol extract of Cinnamomi Ramulus (CR). CR exhibited vascular relaxation against phenylephrine (PE, )-, KCl- and NaF-induced contraction in rat thoracic aorta. In addition, its relaxation was endothelium-independent. Treatment of potassium channel blockers such as gilbenclamide (Gli, ), tetraethylammonium (TEA, 1 mM) and 4-aminopyridine (4-AP, 0.2 mM) did not effect on the relaxation of CR. The relaxant effects were also not inhibited by pre-treatment of rat aorta with L-NAME (), methylene blue (), indomethacin (), and atropine (). However, nifedipine (), L-type channel blocker, in part attenuated the relaxation of CR (), but SK&F96365 (), receptor activated channel blocker and 2-APB (), store operated channel blocker did not affact dilation of CR. These findings suggest that the endothelium-independent relaxation effect of CR is partly related with inhibition of influx via voltage dependent channel.
|
|
|
KEYWORD
|
|
|
Cinnamomi ramulus, vasodilation efficacy, Ca2+ channel
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|